Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT6RIOV)

• DTT Name: Acyl-CoA desaturase (SCD) DTT Info
• Gene Name: SCD

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isoxyl	DMJL10P	Bacterial infection	1A00-1C4Z	Approved	[1]

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aramchol	DMDLGRO	Lipid metabolism disorder	5C52.Z	Phase 2/3	[2]
MK-8245	DMG6KXB	Type-2 diabetes	5A11	Phase 2	[3]

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-(4-benzoylpiperazin-1-yl)thiazole-5-carboxamide	DMJA5Y4	Discovery agent	N.A.	Investigative	[4]
CVT-12012	DMOCKMZ	Diabetic complication	5A2Y	Investigative	[5]
ISIS 147919	DMTE3FJ	Discovery agent	N.A.	Investigative	[6]
MF-152	DMBLUSA	Discovery agent	N.A.	Investigative	[7]
Sterculic acid	DM1PMR3	Discovery agent	N.A.	Investigative	[8]

References

• [1] Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
• [2] The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2014 Dec;12(12):2085-91.e1.
• [3] Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem. 2011 Jul 28;54(14):5082-96.
• [4] Thiazole analog as stearoyl-CoA desaturase 1 inhibitor. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5214-7.
• [5] Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4070-4.
• [6] US patent application no. 7,132,529, Antisense modulation of stearoyl-CoA desaturase expression.
• [7] SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1593-7.
• [8] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015