Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT6VZ78)

• DTT Name: DNA [cytosine-5]-methyltransferase 3B (DNMT3B) DTT Info
• Gene Name: DNMT3B

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]

4 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27376512-Compound-MTC-422	DM1MVQD	N. A.	N. A.	Patented	[2]
PMID27376512-Compound-MTC-423	DM9RSDX	N. A.	N. A.	Patented	[2]
PMID27376512-Compound-MTC-424	DMGNRZU	N. A.	N. A.	Patented	[2]
PMID27376512-Compound-MTC-427	DMWXEZD	N. A.	N. A.	Patented	[2]

17 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(L-)-S-adenosyl-L-homocysteine	DMDUN83	Discovery agent	N.A.	Investigative	[3]
NSC-106084	DM6ID8P	Discovery agent	N.A.	Investigative	[1]
NSC-137546	DMKQYMX	Discovery agent	N.A.	Investigative	[1]
NSC-138419	DMH684Q	Discovery agent	N.A.	Investigative	[1]
NSC-154957	DMW82SA	Discovery agent	N.A.	Investigative	[1]
NSC-158324	DMDR460	Discovery agent	N.A.	Investigative	[1]
NSC-319745	DMF3G06	Discovery agent	N.A.	Investigative	[1]
NSC-345763	DM2UPSV	Discovery agent	N.A.	Investigative	[1]
NSC-348926	DM3TDEO	Discovery agent	N.A.	Investigative	[1]
NSC-401077	DM0214E	Discovery agent	N.A.	Investigative	[1]
NSC-54162	DMW2Q6N	Discovery agent	N.A.	Investigative	[1]
NSC-56071	DMLEN4X	Discovery agent	N.A.	Investigative	[1]
NSC-57893	DMIRK41	Discovery agent	N.A.	Investigative	[1]
NSC-622444	DMM5UT9	Discovery agent	N.A.	Investigative	[1]
NSC-622445	DME35CB	Discovery agent	N.A.	Investigative	[1]
NSC-623548	DMW437Z	Discovery agent	N.A.	Investigative	[1]
S-tubercidinylhomocysteine	DM9UHCY	Discovery agent	N.A.	Investigative	[4]

References

• [1] Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation. Bioorg Med Chem. 2010 Jan 15;18(2):822-9.
• [2] DNA methyltransferase inhibitors: an updated patent review (2012-2015).Expert Opin Ther Pat. 2016 Sep;26(9):1017-30.
• [3] Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors. Bioorg Med Chem Lett. 2009 May 15;19(10):2742-6.
• [4] SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes. Bioorg Med Chem Lett. 2009 May 15;19(10):2747-51.