Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT73U6C)

• DTT Name: Stress-activated protein kinase 2b (p38 beta) DTT Info
• UniProt ID: MK11_HUMAN
• Gene Name: MAPK11

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VX-745	DMJAEG6	Alzheimer disease	8A20	Phase 2	[1]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SB 235699	DMNH8XU	Psoriasis vulgaris	EA90	Discontinued in Phase 1	[1], [2]

13 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[3]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[4]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[4]
KN-62	DMLZ89P	Discovery agent	N.A.	Investigative	[4]
KT-5720	DM9J50F	Discovery agent	N.A.	Investigative	[4]
L-779450	DM51B74	Discovery agent	N.A.	Investigative	[5]
ML-3163	DM3S5UC	Discovery agent	N.A.	Investigative	[6]
ML-3375	DMXJY6W	Discovery agent	N.A.	Investigative	[7]
ML-3403	DMTQWI8	Discovery agent	N.A.	Investigative	[7]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[4]
Ro31-8220	DMDJLF0	Discovery agent	N.A.	Investigative	[4]
RWJ-68354	DMNLVRS	Discovery agent	N.A.	Investigative	[8]
STAUROSPORINONE	DMU2H4K	Discovery agent	N.A.	Investigative	[4]

References

• [1] Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5.
• [2] Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity. J Med Chem. 2003 Dec 18;46(26):5651-62.
• [3] Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47.
• [4] Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
• [5] The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2006 Jan 15;16(2):378-81.
• [6] From imidazoles to pyrimidines: new inhibitors of cytokine release. J Med Chem. 2002 Jun 20;45(13):2733-40.
• [7] Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes. J Med Chem. 2003 Jul 17;46(15):3230-44.
• [8] Imidazopyrimidines, potent inhibitors of p38 MAP kinase. Bioorg Med Chem Lett. 2003 Feb 10;13(3):347-50.