Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT7GN3U)

• DTT Name: Apolipoprotein A-I (APOA1) DTT Info
• Gene Name: APOA1

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CER-001	DMWUQI9	Acute coronary syndrome	BA41	Phase 2	[1]
CSL-112	DMZCG91	Arteriosclerosis	BD40	Phase 2	[2]
CER-522	DMGAW0H	Aortic valve stenosis	BB70	Phase 1	[3]
MDCO-216	DMAQ24G	Arteriosclerosis	BD40	Phase 1	[4]

4 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CRD-5	DMVU4A5	Hyperlipidaemia	5C80	Discontinued in Phase 2	[5]
APP-018	DM5L9I2	Arteriosclerosis	BD40	Discontinued in Phase 1	[6]
AMT-050	DMMKOCL	Cholesterol metabolism disorder	5C8Z	Terminated	[7]
LSI-518P	DMFJPYV	Cardiovascular disease	BA00-BE2Z	Terminated	[8]

References

• [1] Clinical pipeline report, company report or official report of Cerenis.
• [2] CER-001, a HDL-mimetic, stimulates the reverse lipid transport and atherosclerosis regression in high cholesterol diet-fed LDL-receptor deficient mice. Atherosclerosis. 2014 Jan;232(1):110-8.
• [3] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033541)
• [4] MDCO-216 (Apo A-I Milano/POPC Complex) Administered to Cynomolgus Monkeys Induces Pronounced Changes in Plasma Lipids and Apolipoproteins. Circulation. 2011; 124: A10978.
• [5] Emerging antidyslipidemic drugs. Expert Opin Emerg Drugs. 2008 Jun;13(2):363-81.
• [6] Apolipoprotein A-I and its mimetics for the treatment of atherosclerosis. Curr Opin Investig Drugs. 2010 September; 11(9): 989-996.
• [7] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026835)
• [8] Clinical review: The evolving role of HDL in the treatment of high-risk patients with cardiovascular disease. J Clin Endocrinol Metab. 2011 May;96(5):1246-57.