Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT7LCTF)

• DTT Name: Pregnane X receptor (NR1I2) DTT Info
• Gene Name: NR1I2

Molecule-Related Drug & Molecule List

6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
3-keto-lithocholic acid	DM5LUED	Discovery agent	N.A.	Investigative	[1]
Hyperforin	DM2L3PE	Discovery agent	N.A.	Investigative	[2]
pregnenolone-16alpha-carbonitrile	DM0LW7G	Discovery agent	N.A.	Investigative	[3]
schisandrin A	DMWQ480	Discovery agent	N.A.	Investigative	[4]
trihydroxycholestane	DMSP56N	Discovery agent	N.A.	Investigative	[5]
WAY-214950	DM8ODI7	Discovery agent	N.A.	Investigative	[6]

References

• [1] The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3369-74.
• [2] Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier: functional similarities between pig and human PXR. J Pharmacol Exp Ther. 2009 Apr;329(1):141-9.
• [3] An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell. 1998 Jan 9;92(1):73-82.
• [4] Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and inc... J Pharmacol Exp Ther. 2006 Mar;316(3):1369-77.
• [5] Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):223-8.
• [6] Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8.