Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT7YJFO)

• DTT Name: SET and MYND domain-containing protein 2 (SMYD2) DTT Info
• Gene Name: SMYD2

Molecule-Related Drug & Molecule List

6 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
A-893	DM8XHJG	Lung cancer	2C25.0	Preclinical	[1]
AZ505	DMKQ20J	Solid tumour/cancer	2A00-2F9Z	Preclinical	[2]
BAY 598	DMWH19X	Discovery agent	N.A.	Preclinical	[3]
EPZ032597	DMHU742	Solid tumour/cancer	2A00-2F9Z	Preclinical	[4]
EPZ033294	DMDO6NZ	Solid tumour/cancer	2A00-2F9Z	Preclinical	[4]
LLY-507	DMNOE1M	Solid tumour/cancer	2A00-2F9Z	Preclinical	[5]

References

• [1] Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2. ACS Med Chem Lett. 2015 Apr 29;6(6):695-700.
• [2] Structural basis of substrate methylation and inhibition of SMYD2. Structure. 2011 Sep 7;19(9):1262-73.
• [3] Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. J Med Chem. 2016 May 26;59(10):4578-600.
• [4] Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286.
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2714).