Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT7ZMI1)

• DTT Name: Integrin alpha-4/beta-7 (ITGA4/B7) DTT Info
• Gene Name: ITGA4-ITGB7

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MLN0002	DMP2LZ8	Crohn disease	DD70	Approved	[1]

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MORF-057	DMS274E	Crohn disease	DD70	Phase 2	[2]
PN-943	DMUZLKW	Ulcerative colitis	DD71	Phase 2	[3]
TRK-170	DM13G5R	Inflammatory bowel disease	DD72	Phase 2	[4]
GS-1427	DMDDBG1	Inflammation	1A00-CA43.1	Phase 1	[5]

2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
R1295	DMT8V9G	Rheumatoid arthritis	FA20	Discontinued in Phase 1	[6]
TR-14035	DMWD39E	Multiple sclerosis	8A40	Discontinued in Phase 1	[7]

References

• [1] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
• [2] ClinicalTrials.gov (NCT05291689) A Phase 2a, Open-label, Single-arm Study to Evaluate the Efficacy, Safety, and Tolerability of MORF-057 in Adults With Moderately to Severely Active Ulcerative Colitis (EMERALD-1). U.S.National Institutes of Health.
• [3] Single- and Multiple-Dose Pharmacokinetics and Pharmacodynamics of PN-943, a Gastrointestinal-Restricted Oral Peptide Antagonist of alpha4beta7, in Healthy Volunteers. Clin Pharmacol Drug Dev. 2021 Nov;10(11):1263-1278.
• [4] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [5] Clinical pipeline report, company report or official report of Gilead
• [6] Vedolizumab: an 47 integrin inhibitor for inflammatory bowel diseases.Ann Pharmacother.2014 Dec;48(12):1629-35.
• [7] Pharmacokinetics and metabolism of TR-14035, a novel antagonist of a4ss1/a4ss7 integrin mediated cell adhesion, in rat and dog. Xenobiotica. 2005 Apr;35(4):373-89.