General Information of DTT (ID: TT85JO3)

DTT Name 5-HT receptor (5HTR) DTT Info
Gene Name 5HTR

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
6 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metergolin DMJFP6G Hyperprolactinaemia 5A60.1 Approved [1]
Nafronyl DMVMQ1L Cerebrovascular ischaemia 8B1Z Approved [2]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [2]
Pizotyline DMV74ZH Headache 8A80-8A84 Approved [2]
Ramosetron DMH7GN8 Diarrhea-predominant irritable bowel syndrome DD91.01 Approved [1]
Tandospirone DMPHWU6 Anxiety disorder 6B00-6B0Z Approved [1]
------------------------------------------------------------------------------------
⏷ Show the Full List of 6 Approved Drug(s)
10 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fenfluramine DM0762O Dravet syndrome 8A61.11 Phase 3 [3]
ITI-007 DMUQ1DO Depression 6A70-6A7Z Phase 3 [4]
EPX-200 DMWK26Q Dravet syndrome 8A61.11 Phase 2 [5]
EPX-300 DMUXDGZ N. A. N. A. Phase 2 [5]
Lu-AA34893 DM2ZUXK Anxiety disorder 6B00-6B0Z Phase 2 [6]
MIN-117 DMSLIW6 Major depressive disorder 6A70.3 Phase 2 [4]
SEP--4199 DMA12HB Bipolar disorder 6A60 Phase 2 [7]
BF-1 DM7RPSG Cluster headache 8A81.0 Phase 1 [8]
DSP-6745 DMM86OH Parkinson disease 8A00.0 Phase 1 [5]
EPX-100 DMXI9P4 Dravet syndrome 8A61.11 Phase 1 [5]
------------------------------------------------------------------------------------
⏷ Show the Full List of 10 Clinical Trial Drug(s)
3 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ritanserin DM0X36Y Anxiety disorder 6B00-6B0Z Discontinued in Phase 3 [9]
REV-598 DM314CZ Carcinoid syndrome 5B10 Terminated [10]
RGH-2721 DMBCIPO Psychotic disorder 6A20-6A25 Terminated [11]
------------------------------------------------------------------------------------
3 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
EpiCept DMFMWA7 Neuropathic pain 8E43.0 Investigative [12]
MCI DMZ1YGI Discovery agent N.A. Investigative [13]
SB 203106 DMQAO5B Discovery agent N.A. Investigative [14]
------------------------------------------------------------------------------------
Molecule Interaction Atlas

References

1 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Pharmacotherapy for obesity. Drugs. 2005;65(10):1391-418.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 Encyclopedia of Psychopharmacology. Ian Stolerman. 2010. Page(105).
7 ClinicalTrials.gov (NCT03543410) A Clinical Study to Test the Effectiveness of an Investigational Drug to Treat People That Have Major Depressive Episodes When They Have Bipolar 1 Depression. U.S. National Institutes of Health.
8 Serotonin (5-HT2B) receptor. SciBX 4(19); doi:10.1038/scibx.2011.534. May 12 2011
9 Combined treatment of portal hypertension with ritanserin and propranolol in conscious and unrestrained cirrhotic rats. Hepatology. 1992 May;15(5):878-82.
10 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016819)
11 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004008)
12 Emerging therapies for neuropathic pain. Expert Opin Emerg Drugs. 2005 Feb;10(1):95-108.
13 Effect of a serotonin receptor antagonist on interleukin-6-induced pulmonary hypertension in rats. Chest. 2001 Feb;119(2):554-61.
14 5-Hydroxytryptamine mediated contractions in isolated preparations of equine ileum and pelvic flexure: pharmacological characterization of a new 5-HT(4) agonist. J Vet Pharmacol Ther. 2002 Feb;25(1):49-58.