Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT8SJGB)

• DTT Name: Cyclic nucleotide-gated channel alpha-2 (CNGA2) DTT Info
• Gene Name: CNGA2

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
dequalinium	DMXM19W	Myelopathy	8B42	Clinical trial	[1]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
all-trans-retinal	DM6CEVB	Discovery agent	N.A.	Investigative	[2]
L-(cis)-diltiazem	DMK07MI	Discovery agent	N.A.	Investigative	[3]
PIP3	DMJX39N	Discovery agent	N.A.	Investigative	[4]

References

• [1] State-dependent block of CNG channels by dequalinium. J Gen Physiol. 2004 Mar;123(3):295-304.
• [2] All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: a novel role for photoreceptor retinoids in the response to bright light Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8372-7.
• [3] Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature. 1990 Sep 13;347(6289):184-7.
• [4] Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15635-40.