Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT9NXW4)

• DTT Name: Sigma intracellular receptor 2 (TMEM97) DTT Info
• UniProt ID: SGMR2_HUMAN
• Gene Name: TMEM97

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MIN-101	DMCJY35	Schizophrenia	6A20	Phase 3	[1]
CT1812	DMBRKZ7	Alzheimer disease	8A20	Phase 2	[2], [3]

52 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aryl azepine derivative 1	DMA9B0V	N. A.	N. A.	Patented	[4]
Aryl azepine derivative 2	DMI4XBC	N. A.	N. A.	Patented	[4]
Benzamide derivative 1	DMDOCTB	N. A.	N. A.	Patented	[5]
Benzamide derivative 10	DM9PKU2	N. A.	N. A.	Patented	[4]
Benzamide derivative 11	DM4V3Y5	N. A.	N. A.	Patented	[4]
Benzamide derivative 2	DM0UWNY	N. A.	N. A.	Patented	[5]
Benzamide derivative 3	DMFY78L	N. A.	N. A.	Patented	[5]
Benzamide derivative 4	DMNKYL9	N. A.	N. A.	Patented	[5]
Benzamide derivative 7	DM7UEJT	N. A.	N. A.	Patented	[4]
Benzamide derivative 8	DMAIJHC	N. A.	N. A.	Patented	[4]
Benzamide derivative 9	DMVFSJZ	N. A.	N. A.	Patented	[4]
Bicyclo-heptan-2-amine derivative 1	DMGESCP	N. A.	N. A.	Patented	[5]
Bicyclo-heptan-2-amine derivative 2	DM9WUH5	N. A.	N. A.	Patented	[5]
Bicyclo-heptan-2-amine derivative 3	DM8ZRXE	N. A.	N. A.	Patented	[5]
Bicyclo-heptan-2-amine derivative 4	DMPRIS0	N. A.	N. A.	Patented	[5]
Fused aryl carbocycle derivative 1	DMFAM8B	N. A.	N. A.	Patented	[4]
Fused aryl carbocycle derivative 2	DMAQBJP	N. A.	N. A.	Patented	[4]
Fused aryl carbocycle derivative 3	DM5I4CA	N. A.	N. A.	Patented	[4]
Fused aryl carbocycle derivative 4	DMOU8T3	N. A.	N. A.	Patented	[4]
Fused aryl carbocycle derivative 8	DMPBMEU	N. A.	N. A.	Patented	[4]
Fused aryl carbocycle derivative 9	DMQ2X6O	N. A.	N. A.	Patented	[4]
Isoindoline derivative 1	DMD19QC	N. A.	N. A.	Patented	[4]
Isoindoline derivative 2	DMTE0S3	N. A.	N. A.	Patented	[4]
Isoindoline derivative 3	DM2MYL9	N. A.	N. A.	Patented	[4]
Isoindoline derivative 4	DMP1NKI	N. A.	N. A.	Patented	[4]
Isoindoline derivative 5	DMIUTQW	N. A.	N. A.	Patented	[4]
N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl-phenylcarbamate analog 1	DMSU80N	N. A.	N. A.	Patented	[5]
N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl-phenylcarbamate analog 2	DMPW1GI	N. A.	N. A.	Patented	[5]
N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl-phenylcarbamate analog 3	DMZF9TM	N. A.	N. A.	Patented	[5]
Piperazine derivative 7	DM9Y4ZV	N. A.	N. A.	Patented	[5]
Piperazinyl methyl quinazolinone derivative 1	DM7WOD9	N. A.	N. A.	Patented	[4]
Piperazinyl methyl quinazolinone derivative 2	DM913KS	N. A.	N. A.	Patented	[4]
Piperazinyl methyl quinazolinone derivative 3	DMYH4AZ	N. A.	N. A.	Patented	[4]
Piperazinyl norbenzomorphane compound 1	DM3LKTE	N. A.	N. A.	Patented	[4]
Piperazinyl norbenzomorphane compound 2	DMD2CX1	N. A.	N. A.	Patented	[4]
Piperazinyl norbenzomorphane compound 3	DMZYJKG	N. A.	N. A.	Patented	[4]
Piperazinyl norbenzomorphane compound 4	DMRSCJ7	N. A.	N. A.	Patented	[4]
Piperidine derivative 5	DMQ0VK4	N. A.	N. A.	Patented	[5]
Piperidine derivative 6	DM0GCTY	N. A.	N. A.	Patented	[5]
PMID28051882-Compound-Figure9	DMRANS2	N. A.	N. A.	Patented	[5]
PMID28051882-Compound-XI	DMLNA8P	N. A.	N. A.	Patented	[5]
PMID28051882-Compound-XIV	DM1RN89	N. A.	N. A.	Patented	[5]
PMID30185082-Compound-14	DMQU10C	N. A.	N. A.	Patented	[4]
PMID30185082-Compound-27	DMYFLT1	N. A.	N. A.	Patented	[4]
PMID30185082-Compound-28	DMI0WHE	N. A.	N. A.	Patented	[4]
PMID30185082-Compound-53	DM9GX0F	N. A.	N. A.	Patented	[4]
PMID30185082-Compound-54	DMKP14O	N. A.	N. A.	Patented	[4]
PMID30185082-Compound-55	DMW8V4R	N. A.	N. A.	Patented	[4]
PMID30185082-Compound-56	DMLGKYI	N. A.	N. A.	Patented	[4]
PMID30185082-Compound-57	DMNDF1Z	N. A.	N. A.	Patented	[4]
PMID30185082-Compound-63	DMW2S0J	N. A.	N. A.	Patented	[4]
PMID30185082-Compound-64	DMKD470	N. A.	N. A.	Patented	[4]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ANAVEX 1007	DM2U16Z	Melanoma	2C30	Preclinical	[6]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1,3-ditolylguanidine	DM04KS1	Discovery agent	N.A.	Investigative	[7], [8]
SM 21	DM7MSGK	Discovery agent	N.A.	Investigative	[9]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663.
• [5] Are sigma modulators an effective opportunity for cancer treatment A patent overview (1996-2016).Expert Opin Ther Pat. 2017 May;27(5):565-578.
• [6] 2011 Pipeline of Anavex.
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2553).
• [8] Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59(6):350-8.
• [9] The analgesic tropane analogue (+/-)-SM 21 has a high affinity for sigma2 receptors. Life Sci. 1999;64(10):PL131-7.