Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TT9TE0O)

• DTT Name: Mdm2 messenger RNA (MDM2 mRNA) DTT Info
• Gene Name: MDM2

Molecule-Related Drug & Molecule List

6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 16507	DMK69ZR	Solid tumour/cancer	2A00-2F9Z	Investigative	[1]
ISIS 16518	DM24L0S	Solid tumour/cancer	2A00-2F9Z	Investigative	[1]
NSC-66811	DMRVMA5	Discovery agent	N.A.	Investigative	[2]
NU-8231	DMEUV5R	Discovery agent	N.A.	Investigative	[3]
NUTLIN-3	DM5KXFI	Discovery agent	N.A.	Investigative	[4]
PLSQETFSDLWKLLPEN-NH2	DMBN4V6	Discovery agent	N.A.	Investigative	[5]

References

• [1] US patent application no. 6,238,921, Antisense oligonucleotide modulation of human mdm2 expression.
• [2] Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening str... J Med Chem. 2006 Jun 29;49(13):3759-62.
• [3] Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold. J Med Chem. 2006 Oct 19;49(21):6209-21.
• [4] Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature. 2007 Dec 13;450(7172):1001-9.
• [5] Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction. J Med Chem. 2006 Jun 15;49(12):3432-5.