Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTAMQ62)

• DTT Name: Cyclin A2 (CCNA2) DTT Info
• Gene Name: CCNA2

Molecule-Related Drug & Molecule List

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PD-0183812	DMWYP86	Retinoblastoma	2D02.2	Terminated	[1]

22 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2,5-dichloro-N-p-tolylthiophene-3-sulfonamide	DMU5J8Y	Discovery agent	N.A.	Investigative	[2]
3-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)phenol	DMJZK40	Discovery agent	N.A.	Investigative	[3]
4-(phenyldiazenyl)-1H-pyrazole-3,5-diamine	DM54MOP	Discovery agent	N.A.	Investigative	[3]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[3]
6-(3-Amino-benzyloxy)-9H-purin-2-ylamine	DMJ92W0	Discovery agent	N.A.	Investigative	[4]
6-(3-Methyl-benzyloxy)-9H-purin-2-ylamine	DMSW3KN	Discovery agent	N.A.	Investigative	[4]
6-(Cyclohex-3-enylmethoxy)-9H-purin-2-ylamine	DMAYWIN	Discovery agent	N.A.	Investigative	[4]
6-Cyclohexylmethoxy-pyrimidine-2,4,5-triamine	DM9IHYS	Discovery agent	N.A.	Investigative	[5]
6-O-Cyclohexylmethyl Guanine	DMDIW08	Discovery agent	N.A.	Investigative	[6]
aloisine A	DM5U1LN	Discovery agent	N.A.	Investigative	[7]
GW-8510	DML4UMT	Discovery agent	N.A.	Investigative	[8]
MERIOLIN 1	DMJT93H	Discovery agent	N.A.	Investigative	[9]
MERIOLIN 2	DM413XJ	Discovery agent	N.A.	Investigative	[9]
MERIOLIN 3	DMVE95S	Discovery agent	N.A.	Investigative	[9]
MERIOLIN 4	DMIJMZQ	Discovery agent	N.A.	Investigative	[9]
MERIOLIN 5	DMGVLR0	Discovery agent	N.A.	Investigative	[9]
MERIOLIN 6	DMW5AXC	Discovery agent	N.A.	Investigative	[9]
MERIOLIN 7	DM8D3NY	Discovery agent	N.A.	Investigative	[9]
MERIOLIN 8	DM0E95B	Discovery agent	N.A.	Investigative	[9]
NU-6027	DMELYAX	Discovery agent	N.A.	Investigative	[5]
Purvalanol A	DMNQ7TM	Discovery agent	N.A.	Investigative	[10]
RESCOVITINE	DM2IBND	Discovery agent	N.A.	Investigative	[11]

References

• [1] Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases. J Med Chem. 2000 Nov 30;43(24):4606-16.
• [2] Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases, Bioorg. Med. Chem. Lett. 20(13):3863-3867 (2010).
• [3] 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9.
• [4] Probing the ATP ribose-binding domain of cyclin-dependent kinases 1 and 2 with O(6)-substituted guanine derivatives. J Med Chem. 2002 Aug 1;45(16):3381-93.
• [5] 4-Alkoxy-2,6-diaminopyrimidine derivatives: inhibitors of cyclin dependent kinases 1 and 2. Bioorg Med Chem Lett. 2003 Jan 20;13(2):217-22.
• [6] N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2. J Med Chem. 2004 Jul 15;47(15):3710-22.
• [7] Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J Med Chem. 2003 Jan 16;46(2):222-36.
• [8] Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles. Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7.
• [9] Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin com... J Med Chem. 2008 Feb 28;51(4):737-51.
• [10] The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007 Dec 15;408(3):297-315.
• [11] Design, synthesis, and biological evaluation of novel pyrimidine derivatives as CDK2 inhibitors. Eur J Med Chem. 2010 Mar;45(3):1158-66.