Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTAZ3MN)

• DTT Name: Beta-adrenergic receptor kinase 1 (ADRBK1) DTT Info
• Gene Name: GRK2

Molecule-Related Drug & Molecule List

5 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BDBM50173306	DMSTD28	N. A.	N. A.	Patented	[1]
US9493490, C	DMC1YR5	N. A.	N. A.	Patented	[2]
US9493490, D	DMUVC25	N. A.	N. A.	Patented	[2]
US9493490, E	DMFCIGE	N. A.	N. A.	Patented	[2]
US9493490, L	DMJDTSN	N. A.	N. A.	Patented	[2]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BetaARKct	DMN7DJ5	Discovery agent	N.A.	Investigative	[3]
PMID21596927C101	DM7JRHB	Discovery agent	N.A.	Investigative	[4]
PMID24210504C1o	DM4LEUT	Discovery agent	N.A.	Investigative	[5]

References

• [1] G protein-coupled receptor kinase 2 inhibitors and methods for use of the same. US10023564.
• [2] Boron-containing small molecules. US9493490.
• [3] Gene-mediated inhibition of the b-adrenergic receptor kinase: a new therapeutic strategy for heart failure. Minerva Cardioangiol. 2001 Dec;49(6):389-94.
• [4] Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors. Mol Pharmacol. 2011 Aug;80(2):294-303.
• [5] Design and synthesis of novel 3-(benzo[d]oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine derivatives as selective G-protein-coupled receptor kinase-2 and -5 inhibitors. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6711-6.