Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTBOH16)

DTT Name	Retinal pigment epithelium protein (RPE65) DTT Info
Gene Name	RPE65

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Clinical Trial Drug(s)

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5 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AAV2-hRPE65v2	DMJNSLU	Ocular disease	1F00.1Z	Phase 3	[1]
Emixustat	DMH8VMP	Age-related macular degeneration	9B75.0	Phase 2/3	[2]
AAV-RPE65	DMAH6UJ	Leber congenital amaurosis	9B70	Phase 1/2	[3]
Leber's congenital amaurosis gene therapy	DMFHV9L	Leber congenital amaurosis	9B70	Phase 1/2	[4]
TgAAG76	DMNKLZM	Blindness	9D90	Phase 1/2	[5]
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Molecule Interaction Atlas

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References

1	AAV2 gene therapy readministration in three adults with congenital blindness. Sci Transl Med. 2012 Feb 8;4(120):120ra15.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Clinical pipeline report, company report or official report of MeiraGTx.
4	ClinicalTrials.gov (NCT00749957) Phase 1/2 Safety and Efficacy Study of AAV-RPE65 Vector to Treat Leber Congenital Amaurosis. U.S. National Institutes of Health.
5	tgAAG76, an adeno-associated virus delivered gene therapy for the potential treatment of vision loss caused by RPE65 gene abnormalities. Curr Opin Mol Ther. 2010 Aug;12(4):471-7.