Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTCAQMW)

DTT Name	Inosine-5'-monophosphate dehydrogenase (IMPDH) DTT Info
Gene Name	IMPDH

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enteric-coated mycophenolate sodium	DMK659W	Transplant rejection	NE84	Approved	[1]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[2]
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1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VX-944	DME321B	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
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2 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IMS	DMFACQU	Inflammatory bowel disease	DD72	Discontinued in Phase 1	[4]
R-1518	DM2J5AO	Hepatitis C virus infection	1E51.1	Discontinued in Phase 1	[5]
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1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
EPB-415	DMBLSX3	Hepatitis C virus infection	1E51.1	Investigative	[6]
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Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Mycophenolate mofetil, an inhibitor of inosine monophosphate dehydrogenase, causes a paradoxical elevation of GTP in erythrocytes of renal transplant patients. Clin Sci (Lond). 2004 Jul;107(1):63-8.
2	Immune effector cells produce lethal DNA damage in cells treated with a thiopurine. Cancer Res. 2009 Mar 15;69(6):2393-9.
3	Novel inosine monophosphate dehydrogenase inhibitor VX-944 induces apoptosis in multiple myeloma cells primarily via caspase-independent AIF/Endo G pathway. Oncogene. 2005 Sep 1;24(38):5888-96.
4	The novel inosine analogue INO-2002 exerts an anti-inflammatory effect in a murine model of acute lung injury. Shock. 2009 Sep;32(3):258-62.
5	US patent application no. 2010,0092,479, Compositions and methods for treatment of viral diseases.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2625).