Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTCGY2K)

DTT Name	DNA topoisomerase II alpha (TOP2A) DTT Info
Gene Name	TOP2A

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Camsirubicin	DMEZLFT	Soft tissue sarcoma	2B57	Phase 2	[1]
PK1	DMKEV7N	Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]
Annamycin	DMDHJNV	Acute myeloid leukaemia	2A60	Phase 1/2	[3]
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1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NK314	DMY729C	T-cell leukaemia	2A90	Investigative	[4]
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Molecule Interaction Atlas

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References

1	Clinical pipeline report, company report or official report of Monopar Therapeutics.
2	Phase II studies of polymer-doxorubicin (PK1, FCE28068) in the treatment of breast, lung and colorectal cancer. Int J Oncol. 2009 Jun;34(6):1629-36.
3	Effect of structural modification at the 4, 3', and 2' positions of doxorubicin on topoisomerase II poisoning, apoptosis, and cytotoxicity in human melanoma cells. Arch Immunol Ther Exp (Warsz). May-Jun 2007;55(3):193-8.
4	NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform. J Biol Chem. 2008 Aug 29;283(35):23711-20.