General Information of DTT (ID: TTCQIBE)

DTT Name Caspase-1 (CASP1) DTT Info
Gene Name CASP1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Patented Agent(s)
Investigative Drug(s)
4 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
AC-201 DMB0TNL Type-2 diabetes 5A11 Phase 2 [1]
Belnacasan DM2Q50G Epilepsy 8A60-8A68 Phase 2 [2]
Nivocasan DMUX8JZ Fibrosis GA14-GC01 Phase 2 [3]
PRALNACASAN DM73UTG Rheumatoid arthritis FA20 Phase 2 [4]
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2 Patented Agent(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ac-YVAD-cmk DMA1RVN Allergic contact dermatitis EK00 Patented [5]
Ac-YVAD-FMK DM7K256 Allergic contact dermatitis EK00 Patented [5]
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3 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-709049 DMQZW6D N. A. N. A. Terminated [6]
SDZ-224-015 DMY1KE8 Rheumatoid arthritis FA20 Terminated [7]
VE-16084 DMHG70W Rheumatoid arthritis FA20 Terminated [8]
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5 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
M826 DM9NPE4 Discovery agent N.A. Investigative [9]
YVAD DM24LNB Discovery agent N.A. Investigative [10]
Z-VAD-CHO DMCE8K1 Discovery agent N.A. Investigative [11]
Z-YVAD-CHO DM0TP2R Discovery agent N.A. Investigative [11]
Z-YVAD-FMK DMFTBPI Discovery agent N.A. Investigative [12]
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Molecule Interaction Atlas

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 (S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydr... J Pharmacol Exp Ther. 2007 May;321(2):509-16.
3 Combined effects of an antioxidant and caspase inhibitor on the reversal of hepatic fibrosis in rats. Apoptosis. 2013 Dec;18(12):1481-91.
4 Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis. Osteoarthritis Cartilage. 2003 Oct;11(10):738-46.
5 Caspase inhibitors: a review of recently patented compounds (2013-2015).Expert Opin Ther Pat. 2018 Jan;28(1):47-59.
6 Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1). Bioorg Med Chem Lett. 2010 Sep 1;20(17):5184-90.
7 Reduction of inflammation and pyrexia in the rat by oral administration of SDZ 224-015, an inhibitor of the interleukin-1 beta converting enzyme. Br J Pharmacol. 1995 Jun;115(4):601-6.
8 Interleukin-1 beta converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice. Cytokine. 1996 May;8(5):377-86.
9 Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80.
10 Mice deficient in interleukin-1beta converting enzyme resist anorexia induced by central lipopolysaccharide. Am J Physiol. 1999 Nov;277(5 Pt 2):R1435-43.
11 Tethering identifies fragment that yields potent inhibitors of human caspase-1. Bioorg Med Chem Lett. 2006 Feb;16(3):559-62.
12 Different molecular events account for butyrate-induced apoptosis in two human colon cancer cell lines. J Nutr. 2002 Jul;132(7):1812-8.