General Information of DTT (ID: TTD24Y0)

DTT Name Toll-like receptor 3 (TLR3) DTT Info
Gene Name TLR3

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
2 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rintatolimod DMYX7VI Human immunodeficiency virus infection 1C62 Phase 3 [1]
Poly-ICLC DM2570B Glioblastoma multiforme 2A00.0 Phase 2 [2]
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2 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
BCG65-E7 DMAMFXC Anal intraepithelial neoplasia 2E92.5 Discontinued in Phase 3 [3]
IPH-3102 DMY3BMC Solid tumour/cancer 2A00-2F9Z Terminated [4]
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4 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Anti-TLR3 mabs DMN76A4 Autoimmune diabetes 5A10 Investigative [5]
Poly IC-poly arginine DMXA4HY Keratosis ED56 Investigative [5]
Poly-ICR DMUMJ7B Keratosis ED56 Investigative [5]
polyIC DMV486E Discovery agent N.A. Investigative [6]
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Molecule Interaction Atlas

References

1 A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome. PLoS One. 2012;7(3):e31334.
2 Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. J Transl Med. 2007 Feb 12;5:10.
3 Serological response to an HPV16 E7 based therapeutic vaccine in women with high-grade cervical dysplasia. Gynecol Oncol. 2010 Feb;116(2):208-12.
4 Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716.
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1753).
6 Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001 Oct 18;413(6857):732-8.