Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTDEJAU)

• DTT Name: Neurotrophic tyrosine kinase ROR1 (ROR1) DTT Info
• Gene Name: ROR1

Molecule-Related Drug & Molecule List

7 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zilovertamab vedotin	DM1MZAQ	Diffuse large B-cell lymphoma	2A81	Phase 2/3	[1]
Cirmtuzumab	DM98RW0	Chronic lymphocytic leukaemia	2A82.0	Phase 2	[2]
VLS-101	DMLT94F	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
Zilovertamab	DMMEJ6K	Mantle cell lymphoma	2A85.5	Phase 2	[4]
NBE-002	DMTAODR	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[5]
ROR1 CAR-specific Autologous T-Lymphocytes	DM5EUIY	Acute lymphoblastic leukaemia	2A85	Phase 1	[6]
ROR1R-CAR-T Cell	DMIAK9P	leukaemia	2A60-2B33	Phase 1	[7]

References

• [1] ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient-derived xenograft mouse models. Blood. 2021 Jun 17;137(24):3365-3377.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Clinical pipeline report, company report or official report of VelosBio.
• [4] The Anti-ROR1 Monoclonal Antibody Zilovertamab Inhibits the Proliferation of Ovarian and Endometrial Cancer Cells. Pharmaceutics. 2022 Apr 11;14(4):837.
• [5] Clinical pipeline report, company report or official report of NBE-Therapeutics.
• [6] ClinicalTrials.gov (NCT02706392) Genetically Modified T-Cell Therapy in Treating Patients With Advanced ROR1+ Malignancies
• [7] ClinicalTrials.gov (NCT02194374) Autologous ROR1R-CAR-T Cells for Chronic Lymphocytic Leukemia (CLL)