Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTDWHC3)

DTT Name	Interleukin 4 receptor alpha (IL4R) DTT Info
Gene Name	IL4R

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dupilumab	DMOAD2Y	Atopic dermatitis	EA80	Approved	[1]
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7 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CBP-201	DMWYNN1	Atopic dermatitis	EA80	Phase 3	[2]
SAR231893	DMHFBOG	Asthma	CA23	Phase 3	[1]
Aerovant	DMUB8WN	Asthma	CA23	Phase 2a	[3]
Altrakincept	DMLSK01	Asthma	CA23	Phase 2	[4]
AZD1402	DM73O6I	Asthma	CA23	Phase 2	[5]
PRX-321	DM7YWVT	Solid tumour/cancer	2A00-2F9Z	Phase 2	[6]
SAR-156597	DMUICJD	Idiopathic pulmonary fibrosis	CB03.4	Phase 2	[7]
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⏷ Show the Full List of 7 Clinical Trial Drug(s)

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMG 317	DMUO3T2	Asthma	CA23	Discontinued in Phase 1	[8]
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2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
APG-201	DM0BVJN	Solid tumour/cancer	2A00-2F9Z	Investigative	[7]
PRS-060	DM8GCHX	Asthma	CA23	Investigative	[7]
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Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med. 2013 Jun 27;368(26):2455-66.
2	Preclinical immunological characterization of rademikibart (CBP-201), a next-generation human monoclonal antibody targeting IL-4Ralpha, for the treatment of Th2 inflammatory diseases. Sci Rep. 2023 Jul 31;13(1):12411.
3	Aerovance starts trial of Aerovant for uncontrolled asthma. Aerovance. March 3, 2009.
4	The potential of biologics for the treatment of asthma. Nat Rev Drug Discov. 2012 Dec;11(12):958-72.
5	Elarekibep (PRS-060/AZD1402), a new class of inhaled Anticalin medicine targeting IL-4Ra for type 2 endotype asthma. J Allergy Clin Immunol. 2023 Apr;151(4):966-975.
6	Convection-enhanced drug delivery of interleukin-4 Pseudomonas exotoxin (PRX321): increased distribution and magnetic resonance monitoring. J Pharmacol Exp Ther. 2009 Aug;330(2):520-5.
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1697).
8	Clinical pipeline report, company report or official report of Amgen (2009).