Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTE5J6X)

• DTT Name: Diphosphomevalonate decarboxylase (MVD) DTT Info
• Gene Name: MVD

Molecule-Related Drug & Molecule List

12 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2,2-difluoromevalonate 5-diphosphate	DMKXFDA	Discovery agent	N.A.	Investigative	[1]
2-fluoromevalonate 5-diphosphate	DMEQRHY	Discovery agent	N.A.	Investigative	[2]
6-fluoromevalonate 5-diphosphate	DMPZ92X	Discovery agent	N.A.	Investigative	[3]
6-fluoromevalonate pyrophosphate	DMZ26LS	Discovery agent	N.A.	Investigative	[4]
analog 3 (Vlattas et al., 1996)	DMMKGT4	Discovery agent	N.A.	Investigative	[4]
diphosphoglycolyl proline	DM28NIU	Discovery agent	N.A.	Investigative	[3]
P'-geranyl 2-fluoromevalonate 5-diphosphate	DMNY187	Discovery agent	N.A.	Investigative	[3]
P'-geranyl 3,5,7-trihydroxy-3-methylheptanate 7-diphosphate	DMJ4SIA	Discovery agent	N.A.	Investigative	[5]
P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate	DMO9BUR	Discovery agent	N.A.	Investigative	[5]
P'-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphate	DM2395E	Discovery agent	N.A.	Investigative	[5]
PMID17888661C18	DMLPC17	Discovery agent	N.A.	Investigative	[1]
PMID17888661C19	DMRWTHA	Discovery agent	N.A.	Investigative	[1]

References

• [1] Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6164-8.
• [2] Inhibition of mevalonate 5-diphosphate decarboxylase by fluorinated substrate analogs. Biochim Biophys Acta. 2006 Jul;1760(7):1080-7.
• [3] Human mevalonate diphosphate decarboxylase: characterization, investigation of the mevalonate diphosphate binding site, and crystal structure. Arch Biochem Biophys. 2008 Dec 1;480(1):58-67.
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 642).
• [5] Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase. Org Lett. 2006 Mar 16;8(6):1013-6.