Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTEBMN7)

• DTT Name: Long transient receptor potential channel 2 (TRPM2) DTT Info
• Gene Name: TRPM2

Molecule-Related Drug & Molecule List

7 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[1]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[2]
ADP ribose	DMQ1F7J	Discovery agent	N.A.	Investigative	[3]
cADPR	DMLKZQH	Discovery agent	N.A.	Investigative	[4]
GEA 3162	DMBGWEK	Discovery agent	N.A.	Investigative	[5]
NAADP	DM51DW6	Discovery agent	N.A.	Investigative	[4]
OAADPR	DM458IH	Discovery agent	N.A.	Investigative	[6]

References

• [1] Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). Br J Pharmacol. 2008 Mar;153(6):1324-30.
• [2] Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol. 2006 Jun;148(3):264-73.
• [3] ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature. 2001 May 31;411(6837):595-9.
• [4] Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. FASEB J. 2006 May;20(7):962-4.
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 494).
• [6] Metabolite of SIR2 reaction modulates TRPM2 ion channel. J Biol Chem. 2006 May 19;281(20):14057-65.