Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTETX6Q)

• DTT Name: Mixed lineage kinase 3 (MAP3K11) DTT Info
• Gene Name: MAP3K11

Molecule-Related Drug & Molecule List

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CEP-5104	DMV43GY	Discovery agent	N.A.	Investigative	[1]
CEP-6331	DMNXBTD	Discovery agent	N.A.	Investigative	[1]
CEP1349	DMOAZX5	Discovery agent	N.A.	Investigative	[2]
PMID24044867C8	DML4KMP	Discovery agent	N.A.	Investigative	[3]
URMC-099	DMCJXWK	Discovery agent	N.A.	Investigative	[3]

References

• [1] Mixed-lineage kinase 1 and mixed-lineage kinase 3 subtype-selective dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: optimization, mixed-linea... J Med Chem. 2008 Sep 25;51(18):5680-9.
• [2] Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5.
• [3] Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56(20):8032-48.