Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTEX3SI)

DTT Name	MHC class I NK cell receptor 2DL3 (CD158b2) DTT Info
Gene Name	KIR2DL3

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Clinical Trial Drug(s)

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3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IPH-2101	DMDUVCZ	Multiple myeloma	2A83	Phase 2	[1]
IPH-2102	DMPBR0D	Acute myeloid leukaemia	2A60	Phase 2	[1]
mab 1-7F9	DMQOBH4	Multiple myeloma	2A83	Phase 2	[2]
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Molecule Interaction Atlas

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References

1	Daratumumab-mediated lysis of primary multiple myeloma cells is enhanced in combination with the human anti-KIR antibody IPH2102 and lenalidomide. Haematologica. 2015 Feb;100(2):263-8.
2	Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12879-84.