Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTFQEMX)

• DTT Name: Casein kinase I alpha (CSNK1A1) DTT Info
• Gene Name: CSNK1A1

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BTX-A51	DMC8XHQ	Advanced solid tumour	2A00-2F9Z	Phase 1	[1]

1 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9096594, 3	DM8UOKE	N. A.	N. A.	Patented	[2]

2 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
D-4476	DMHD3R8	Chronic lymphocytic leukaemia	2A82.0	Preclinical	[3]
IC261	DMXB95R	Pancreatic cancer	2C10	Preclinical	[4]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID24900428C14	DMU4BL2	Discovery agent	N.A.	Investigative	[5]

References

• [1] Clinical pipeline report, company report or official report of BioTheryX.
• [2] Kinase inhibitors and methods of use thereof. US9096594.
• [3] Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization. Eur J Med Chem. 2012 Oct;56:30-8.
• [4] Crystal structure of a conformation-selective casein kinase-1 inhibitor. J Biol Chem. 2000 Jun 30;275(26):20052-60.
• [5] Structure-Based Design of Potent and Selective CK1gamma Inhibitors. ACS Med Chem Lett. 2012 Oct 18;3(12):1059-64.