Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTG2A6F)

• DTT Name: Excitatory amino acid transporter 3 (SLC1A1) DTT Info
• Gene Name: SLC1A1

Molecule-Related Drug & Molecule List

5 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
D-aspartic acid	DM7Z892	Discovery agent	N.A.	Investigative	[1]
DL-TBOA	DM2HGNU	Discovery agent	N.A.	Investigative	[2]
L-beta-BA	DMENM1B	Discovery agent	N.A.	Investigative	[3]
NBI-59159	DM7S5Y4	Discovery agent	N.A.	Investigative	[4]
[3H]ETB-TBOA	DMWGY61	Discovery agent	N.A.	Investigative	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 870).
• [2] Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2407-10.
• [3] The substituted aspartate analogue L-beta-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3. Neuropharmacology. 2005 Nov;49(6):850-61.
• [4] Ligands targeting the excitatory amino acid transporters (EAATs). Curr Top Med Chem. 2006;6(17):1897-906.
• [5] Characterization of the tritium-labeled analog of L-threo-beta-benzyloxyaspartate binding to glutamate transporters. Mol Pharmacol. 2007 Jan;71(1):294-302.