Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTG4R8V)

DTT Name	Growth hormone-releasing hormone receptor (GHRHR) DTT Info
Gene Name	GHRHR

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Discontinued Drug(s)

Approved Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sermorelin	DM25HP1	Pediatric growth disorder	FB86	Approved	[1]
Tesamorelin	DM9GP85	HIV-associated lipodystrophy	1C62.1	Approved	[2]
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4 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AKL-0707	DME6OXB	Lipodystrophy	EF01	Discontinued in Phase 2	[3]
Examorelin	DMGJMQH	Growth hormone deficiency	5A61.3	Discontinued in Phase 2	[4]
L-692429	DMLHE5A	Growth hormone deficiency	5A61.3	Discontinued in Phase 1	[5]
NNC-26-0762	DMLTYFI	Growth hormone deficiency	5A61.3	Terminated	[6]
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1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mutated growth hormone	DMAY50R	Acromegaly	5A60.0	Investigative	[7]
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Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Sermorelin: a better approach to management of adult-onset growth hormone insufficiency Clin Interv Aging. 2006;1(4):307-8.
2	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
3	A super-agonist of growth hormone-releasing hormone causes rapid improvement of nutritional status in patients with chronic kidney disease. Kidney Int. 2010 Mar;77(5):450-8.
4	Hexarelin is a stronger GH-releasing peptide than GHRH in normal cycling women but not in anorexia nervosa. J Endocrinol Invest. 1997 May;20(5):257-63.
5	Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrel... Mol Endocrinol. 2005 Sep;19(9):2400-11.
6	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010046)
7	Treatment strategies for acromegaly. Expert Opin Emerg Drugs. 2005 Nov;10(4):875-90.