Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTG90S6)

• DTT Name: Human immunodeficiency virus Glycoprotein 41 (HIV gp41) DTT Info
• Gene Name: HIV gp41

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enfuvirtide	DM7YPM1	Human immunodeficiency virus infection	1C62	Approved	[1]

7 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sifuvirtide	DMMIWCE	Human immunodeficiency virus infection	1C62	Phase 3	[2]
ITV-1	DMCJX79	Human immunodeficiency virus infection	1C62	Phase 2	[3]
MaC46/M87o	DMIRG15	Human immunodeficiency virus-1 infection	1C62	Phase 1/2	[4]
T-1249	DMB2NP8	Human immunodeficiency virus infection	1C62	Phase 1/2	[5]
Combinectin	DMTLP1N	Human immunodeficiency virus infection	1C62	Phase 1	[6]
Gp41 HIV-1 vaccine	DM9JV80	Human immunodeficiency virus infection	1C62	Phase 1	[7]
Multi-envelope HIV vaccine	DMAGCHE	Human immunodeficiency virus infection	1C62	Phase 1	[8]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [2] Broad antiviral activity and crystal structure of HIV-1 fusion inhibitor sifuvirtide.J Biol Chem.2012 Feb 24;287(9):6788-96.
• [3] Clinical pipeline report, company report or official report of Immunotech Laboratories.
• [4] DOI: 10.1038/mt.sj.6300124
• [5] HIV entry inhibitors in clinical development. Curr Opin Pharmacol. 2002 Oct;2(5):523-8.
• [6] Clinical pipeline report, company report or official report of ViiV Healthcare.
• [7] Phase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C/B' HIV-1 candidate vaccine. PLoS One. 2010 Jan 25;5(1):e8617.
• [8] An assessment of the role of chimpanzees in AIDS vaccine research. Altern Lab Anim. 2008 Sep;36(4):381-428.