Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTGC95K)

DTT Name	SET domain containing 8 (KMT5A) DTT Info
Gene Name	KMT5A

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Preclinical Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

2 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MS2177	DMDEJBQ	Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[1]
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2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MS453	DMBTPDL	Discovery agent	N.A.	Investigative	[2]
nahuoic acid A	DM1LWMU	Discovery agent	N.A.	Investigative	[3]
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Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286.
2	Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase. J Med Chem. 2016 Nov 10;59(21):9881-9889.
3	Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8. Org Lett. 2013 Jan 18;15(2):414-7.