Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTGECUM)

DTT Name	Cot oncogene messenger RNA (MAP3K8 mRNA) DTT Info
Gene Name	MAP3K8

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

9 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
8-chloro-quinoline-3-carbonitrile	DMFNUHQ	Discovery agent	N.A.	Investigative	[1]
ISIS 116359	DM280AE	Discovery agent	N.A.	Investigative	[2]
ISIS 116360	DMFEZHM	Discovery agent	N.A.	Investigative	[2]
ISIS 116361	DMWBQHS	Discovery agent	N.A.	Investigative	[2]
ISIS 116362	DM7M1UB	Discovery agent	N.A.	Investigative	[2]
ISIS 116363	DMXKAJP	Discovery agent	N.A.	Investigative	[2]
ISIS 116414	DM4Q3JO	Discovery agent	N.A.	Investigative	[2]
NSC-686549	DM0164B	Discovery agent	N.A.	Investigative	[3]
Tpl2 kinase inhibitor	DMHATCZ	Discovery agent	N.A.	Investigative	[4]
------------------------------------------------------------------------------------


⏷ Show the Full List of 9 Investigative Drug(s)

Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood. J Biol Chem. 2007 Nov 16;282(46):33295-304.
2	US patent application no. 6,265,216, Antisense modulation of cot oncogene expression.
3	A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8.
4	Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5288-92.