General Information of DTT (ID: TTGPQ0F)

DTT Name Prolyl endopeptidase FAP (FAP) DTT Info
Gene Name FAP

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
6 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Talabostat DM1IZ5D Constitutional neutropenia 4B00.0 Phase 3 [1]
BIBH 1 DMHYZEK Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Sibrotuzumab DMT4UC1 Metastatic colorectal cancer 2B91 Phase 2 [2]
AMG 506 DMG64PE Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
NG-641 DMITVHM Solid tumour/cancer 2A00-2F9Z Phase 1 [4]
RG7461 DM5OTGR Solid tumour/cancer 2A00-2F9Z Phase 1 [5]
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⏷ Show the Full List of 6 Clinical Trial Drug(s)
2 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
FAP5-DM1 DMYFVZ3 Solid tumour/cancer 2A00-2F9Z Preclinical [6]
PT630 DM9SY8E Colon cancer 2B90.Z Preclinical [7]
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4 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
ARI-3099 DMIMD0T Discovery agent N.A. Investigative [8]
FE-999040 DM3UCWM Solid tumour/cancer 2A00-2F9Z Investigative [9]
MIP-1231 DM2IGD1 Solid tumour/cancer 2A00-2F9Z Investigative [9]
VA-119930 DMG53XV Inflammatory bowel disease DD72 Investigative [9]
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Molecule Interaction Atlas

References

1 Phase II trial of single agent Val-boroPro (Talabostat) inhibiting Fibroblast Activation Protein in patients with metastatic colorectal cancer. Cancer Biol Ther. 2007 Nov;6(11):1691-9.
2 A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin Cancer Res. 2003 May;9(5):1639-47.
3 Clinical pipeline report, company report or official report of Amgen.
4 Clinical pipeline report, company report or official report of PsiOxus Therapeutics.
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 Effective immunoconjugate therapy in cancer models targeting a serine protease of tumor fibroblasts. Clin Cancer Res. 2008 Jul 15;14(14):4584-92.
7 Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J Clin Invest. 2009 Dec;119(12):3613-25.
8 Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. J Med Chem. 2013 May 9;56(9):3467-77.
9 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2365).