Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTH24WI)

DTT Name	RAC-beta serine/threonine-protein kinase (AKT2) DTT Info
Gene Name	AKT2

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Investigative Drug(s)

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3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Akt inhibitor VIII	DMDVIT1	Discovery agent	N.A.	Investigative	[1]
PHT-427	DMI96Y3	Discovery agent	N.A.	Investigative	[2]
PMID20005102C1	DMMESBW	Discovery agent	N.A.	Investigative	[3]
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Molecule Interaction Atlas

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References

1	Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorg Med Chem Lett. 2005 Feb 1;15(3):761-4.
2	Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther. 2010 Mar;9(3):706-17.
3	2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles. Bioorg Med Chem Lett. 2010 Jan 15;20(2):679-83.