Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTH4QIS)

DTT Name	Integrin alpha-5/beta-1 (ITGA5/B1) DTT Info
UniProt ID	ITA5_HUMAN-ITB1_HUMAN
Gene Name	ITGA5-ITGB1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ATN-161	DM4T9RS	Renal cell carcinoma	2C90	Phase 2	[1]
Volociximab	DMNQG24	Non-small-cell lung cancer	2C25.Y	Phase 2	[2]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[3]
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1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
F-200	DMVWZN1	Ocular disease	1F00.1Z	Terminated	[4]
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Molecule Interaction Atlas

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References

1	A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol Cancer Ther. 2006 Sep;5(9):2271-80.
2	Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent. J Exp Ther Oncol. 2006;5(4):273-86.
3	Gene electrotransfer of plasmid AMEP, an integrin-targeted therapy, has antitumor and antiangiogenic action in murine B16 melanoma.Gene Ther.2015 Jul;22(7):578-90.
4	US patent application no. 8,541,413, Sustained release eye drop formulations.