Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTH4VJL)

• DTT Name: Histone acetyltransferase KAT6B (KAT6B) DTT Info
• Gene Name: KAT6B

Molecule-Related Drug & Molecule List

6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
anacardic acid	DMAS5BI	Discovery agent	N.A.	Investigative	[1]
C646	DMCOQKH	Discovery agent	N.A.	Investigative	[2]
garcinol	DM6B9ZG	Discovery agent	N.A.	Investigative	[3]
I-CBP112	DMQX3W6	Discovery agent	N.A.	Investigative	[4]
MG149	DM7V58G	Discovery agent	N.A.	Investigative	[5]
SGC-CBP30	DMTLRGZ	Discovery agent	N.A.	Investigative	[6]

References

• [1] Small molecule modulators of histone acetyltransferase p300. J Biol Chem. 2003 May 23;278(21):19134-40.
• [2] Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol. 2010 May 28;17(5):471-82.
• [3] Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene e... J Biol Chem. 2004 Aug 6;279(32):33716-26.
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2735).
• [5] 6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem. 2012 Jan;47(1):337-44.
• [6] Bromodomains and their pharmacological inhibitors. ChemMedChem. 2014 Mar;9(3):438-64.