Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTH5TC2)

• DTT Name: NF-kappa-B-activating kinase (TBK1) DTT Info
• Gene Name: TBK1

Molecule-Related Drug & Molecule List

14 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aminopyrimidine derivative 10	DM2TF64	N. A.	N. A.	Patented	[1]
Aminopyrimidine derivative 6	DMZF0DK	N. A.	N. A.	Patented	[1]
Aminopyrimidine derivative 7	DMW98RI	N. A.	N. A.	Patented	[1]
Aminopyrimidine derivative 8	DML83KW	N. A.	N. A.	Patented	[1]
Aminopyrimidine derivative 9	DM5VRXW	N. A.	N. A.	Patented	[1]
PMID26293650-Compound-34	DMHXT12	N. A.	N. A.	Patented	[1]
PMID26293650-Compound-35	DMPG8MF	N. A.	N. A.	Patented	[1]
Pyrimidinyl compound 1	DMYKHQ8	N. A.	N. A.	Patented	[1]
Pyrimidinyl compound 2	DM9TW5O	N. A.	N. A.	Patented	[1]
Pyrimidinyl compound 3	DMOE2FZ	N. A.	N. A.	Patented	[1]
Pyrimidinyl compound 4	DM53O9Y	N. A.	N. A.	Patented	[1]
Pyrimidinyl compound 5	DMCKBGM	N. A.	N. A.	Patented	[1]
Pyrimidinyl compound 6	DML2E8S	N. A.	N. A.	Patented	[1]
Pyrimidinyl compound 7	DMMYW2L	N. A.	N. A.	Patented	[1]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MRT67307	DMYRCHG	Discovery agent	N.A.	Investigative	[2]
PMID23099093C17d	DMWS7O9	Discovery agent	N.A.	Investigative	[3]

References

• [1] TBK1 inhibitors: a review of patent literature (2011 - 2014).Expert Opin Ther Pat. 2015;25(12):1385-96.
• [2] Novel cross-talk within the IKK family controls innate immunity. Biochem J. 2011 Feb 15;434(1):93-104.
• [3] Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73.