Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTH8FZW)

DTT Name	Signal transducer and activator of transcription 3 (STAT3) DTT Info
Gene Name	STAT3

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[1]
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13 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[2]
Golotimod	DMKZN3A	Immune System disease	4A01-4B41	Phase 2	[3]
Atiprimod	DM84YEC	Multiple myeloma	2A83	Phase 1/2	[4]
GLG-801	DMY1CP9	Chronic lymphocytic leukaemia	2A82.0	Phase 1/2	[2]
IMX-110	DMNHZS4	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[2]
NT219	DMOYS1N	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[5]
OPB-31121	DM6VGO3	Hepatocellular carcinoma	2C12.02	Phase 1/2	[6]
WP-1066	DMUGHWR	Recurrent glioblastoma	2A00.00	Phase 1/2	[2]
DSP-0337	DM4ZCY0	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
OPB-111077	DM7YFW5	Haematological malignancy	2B33.Y	Phase 1	[8]
OPB-51602	DM760FA	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
TAK-114	DMTXE19	Ulcerative colitis	DD71	Phase 1	[10]
WP1220	DM8RNSB	Cutaneous T-cell lymphoma	2B01	Phase 1	[11]
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⏷ Show the Full List of 13 Clinical Trial Drug(s)

50 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin analog 1	DM4765M	N. A.	N. A.	Patented	[12]
Curcumin analog 2	DMZ8S6X	N. A.	N. A.	Patented	[12]
Flavonoid derivative 1	DMCQP0B	N. A.	N. A.	Patented	[12]
Flavonoid derivative 2	DMWZARV	N. A.	N. A.	Patented	[12]
Flavonoid derivative 3	DMT7ZEL	N. A.	N. A.	Patented	[12]
Flavonoid derivative 4	DMMOSVD	N. A.	N. A.	Patented	[12]
Flavonoid derivative 5	DMTWAJX	N. A.	N. A.	Patented	[12]
Gold-complexed thiosaccharide derivative 1	DMT1EH9	N. A.	N. A.	Patented	[12]
Gold-complexed thiosaccharide derivative 2	DM9U4OZ	N. A.	N. A.	Patented	[12]
Gold-complexed thiosaccharide derivative 3	DMMOGL8	N. A.	N. A.	Patented	[12]
Oxazole derivative 1	DM7Y2RL	N. A.	N. A.	Patented	[12]
Peptide analog 7	DMKYOLV	N. A.	N. A.	Patented	[12]
Peptidomimetic analog 1	DMMP9N7	N. A.	N. A.	Patented	[12]
Peptidomimetic analog 2	DMN2VZW	N. A.	N. A.	Patented	[12]
Peptidomimetic analog 3	DMPWS9N	N. A.	N. A.	Patented	[12]
Peptidomimetic analog 4	DM9Q0JS	N. A.	N. A.	Patented	[12]
Peptidomimetic analog 5	DMF0DE2	N. A.	N. A.	Patented	[12]
Platinum IV complexe 1	DM8OYI4	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-10	DMP8RQ4	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-11	DMWMZE4	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-12	DMTSQXE	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-13	DMBUZHO	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-20	DMF9J0Y	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-21	DMLMQD4	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-22	DM43Z1G	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-42	DM2E6M7	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-44	DMOJ52P	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-50	DML5I9K	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-51	DMV6GIC	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-52	DMSZWAM	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-53	DMS6EDU	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-54	DMY8FZA	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-Figure16	DMNEGA0	N. A.	N. A.	Patented	[12]
PMID26394986-Compound-Figure17	DMEGBHP	N. A.	N. A.	Patented	[12]
Pyrazole derivative 62	DMN53R0	N. A.	N. A.	Patented	[12]
Pyrazole derivative 63	DMTVAJ0	N. A.	N. A.	Patented	[12]
Pyrazole derivative 64	DMXAURE	N. A.	N. A.	Patented	[12]
Pyrazole derivative 65	DMYTLRJ	N. A.	N. A.	Patented	[12]
Pyrazole derivative 66	DMBYWJI	N. A.	N. A.	Patented	[12]
Quinoline carboxamide derivative 1	DMW5YJB	N. A.	N. A.	Patented	[12]
Quinoline carboxamide derivative 2	DM9XQBG	N. A.	N. A.	Patented	[12]
Quinoline carboxamide derivative 3	DMCAS85	N. A.	N. A.	Patented	[12]
Salicylic acid derivative 1	DMB79QJ	N. A.	N. A.	Patented	[12]
Salicylic acid derivative 2	DMD8C9S	N. A.	N. A.	Patented	[12]
Salicylic acid derivative 3	DM4OGKH	N. A.	N. A.	Patented	[12]
Salicylic acid derivative 4	DM4MAHK	N. A.	N. A.	Patented	[12]
Salicylic acid derivative 5	DM3OZ0F	N. A.	N. A.	Patented	[12]
Salicylic acid derivative 6	DMLBEPW	N. A.	N. A.	Patented	[12]
Salicylic acid derivative 7	DMJFHVN	N. A.	N. A.	Patented	[12]
Tri-substituted purine derivative 1	DM7NTO9	N. A.	N. A.	Patented	[12]
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⏷ Show the Full List of 50 Patented Agent(s)

1 #N/A Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
#N/A	DM1HIEZ	N. A.	N. A.	#N/A	[12]
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1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GNF-PF-1399	DM183RV	Discovery agent	N.A.	Investigative	[13]
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Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Effects of acitretin on the expression of signaling pathway-related genes in epidermal squamous-cell carcinoma cells. Zhonghua Zhong Liu Za Zhi. 2006 Jan;28(1):21-4.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	National Cancer Institute Drug Dictionary (drug id 617379).
4	Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
5	Clinical pipeline report, company report or official report of Purple Biotech.
6	OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. Cancer Lett. 2013 Jul 10;335(1):145-52.
7	Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cells. J Exp Clin Cancer Res. 2019 Jul 5;38(1):289.
8	Phase I Dose-Finding Study of OPB-111077, a Novel STAT3 Inhibitor, in Patients with Advanced Hepatocellular Carcinoma. Cancer Res Treat. 2019 Apr;51(2):510-518.
9	Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies. Ann Oncol. 2015 May;26(5):998-1005.
10	Clinical pipeline report, company report or official report of Gastroenterology.
11	Clinical pipeline report, company report or official report of Moleculin Biotech.
12	A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421.
13	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.