General Information of DTT (ID: TTH9VL3)

DTT Name Plasmodium Plasmepsin 1 (Malaria PLA1) DTT Info
Gene Name Malaria PLA1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Investigative Drug(s)
1 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pepstatin DM9S1EA Malaria 1F40-1F45 Terminated [1]
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6 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
E-64 DMMOPAK Discovery agent N.A. Investigative [2]
KNI-10006 DMMISH6 Discovery agent N.A. Investigative [3]
L-mannitol derivative DMK12C0 Discovery agent N.A. Investigative [4]
Leupeptin DMU075F Malaria 1F40-1F45 Investigative [1]
PS-777621 DM3F7SD Discovery agent N.A. Investigative [5]
SC-5003 DM2DU80 Discovery agent N.A. Investigative [6]
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⏷ Show the Full List of 6 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10.
2 Antimalarial synergy of cysteine and aspartic protease inhibitors. Antimicrob Agents Chemother. 1998 Sep;42(9):2254-8.
3 alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases. Bioorg Med Chem. 2009 Aug 15;17(16):5933-49.
4 Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations. J Med Chem. 2005 Sep 22;48(19):6090-106.
5 High antiplasmodial activity of novel plasmepsins I and II inhibitors. J Med Chem. 2006 Dec 14;49(25):7440-9.
6 Protease inhibitors: current status and future prospects. J Med Chem. 2000 Feb 10;43(3):305-41.