Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTH9VL3)

• DTT Name: Plasmodium Plasmepsin 1 (Malaria PLA1) DTT Info
• Gene Name: Malaria PLA1

Molecule-Related Drug & Molecule List

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pepstatin	DM9S1EA	Malaria	1F40-1F45	Terminated	[1]

6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
E-64	DMMOPAK	Discovery agent	N.A.	Investigative	[2]
KNI-10006	DMMISH6	Discovery agent	N.A.	Investigative	[3]
L-mannitol derivative	DMK12C0	Discovery agent	N.A.	Investigative	[4]
Leupeptin	DMU075F	Malaria	1F40-1F45	Investigative	[1]
PS-777621	DM3F7SD	Discovery agent	N.A.	Investigative	[5]
SC-5003	DM2DU80	Discovery agent	N.A.	Investigative	[6]

References

• [1] Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10.
• [2] Antimalarial synergy of cysteine and aspartic protease inhibitors. Antimicrob Agents Chemother. 1998 Sep;42(9):2254-8.
• [3] alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases. Bioorg Med Chem. 2009 Aug 15;17(16):5933-49.
• [4] Synthesis of malarial plasmepsin inhibitors and prediction of binding modes by molecular dynamics simulations. J Med Chem. 2005 Sep 22;48(19):6090-106.
• [5] High antiplasmodial activity of novel plasmepsins I and II inhibitors. J Med Chem. 2006 Dec 14;49(25):7440-9.
• [6] Protease inhibitors: current status and future prospects. J Med Chem. 2000 Feb 10;43(3):305-41.