Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTH9WF6)

• DTT Name: Dibasic-processing enzyme (Furin) DTT Info
• Gene Name: FURIN

Molecule-Related Drug & Molecule List

3 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9266828, B	DMYUDCE	N. A.	N. A.	Patented	[1]
US9266828, C	DMQEL1W	N. A.	N. A.	Patented	[1]
US9266828, E	DMYUL2X	N. A.	N. A.	Patented	[1]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DecRVKRCMK	DMAUILH	Coronavirus infection	1D92	Preclinical	[2]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
furin inhibitor peptide	DM78NOM	Discovery agent	N.A.	Investigative	[3]
MI-1148	DMCN91V	Discovery agent	N.A.	Investigative	[4]
peptide 18	DMIDP1R	Discovery agent	N.A.	Investigative	[5]

References

• [1] Inhibitors of Furin and other pro-protein convertases. US9266828.
• [2] Decanoyl-Arg-Val-Lys-Arg-Chloromethylketone: An Antiviral Compound That Acts against Flaviviruses through the Inhibition of Furin-Mediated prM Cleavage. Viruses. 2019 Oct 31;11(11):1011.
• [3] Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens. J Biol Chem. 2007 Jul 20;282(29):20847-53.
• [4] Novel Furin Inhibitors with Potent Anti-infectious Activity. ChemMedChem. 2015 Jul;10(7):1218-31.
• [5] Design, synthesis, and structure-activity relationship studies of a potent PACE4 inhibitor. J Med Chem. 2014 Jan 9;57(1):98-109.