General Information of DTT (ID: TTHE657)

DTT Name Bromodomain-containing protein 3 (BRD3) DTT Info
Gene Name BRD3

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
1 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
ABBV-744 DMTEA9C Acute myeloid leukaemia 2A60 Phase 1 [1]
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5 Patented Agent(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID26924192-Compound-102 DMEJ107 N. A. N. A. Patented [2]
PMID26924192-Compound-103 DMWOCP7 N. A. N. A. Patented [2]
PMID26924192-Compound-104 DM346EU N. A. N. A. Patented [2]
PMID26924192-Compound-105 DMAWLGI N. A. N. A. Patented [2]
Pyrrolo-pyrrolone derivative 1 DMN4SE5 N. A. N. A. Patented [2]
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5 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
GW841819X DMRL9IN Discovery agent N.A. Investigative [3]
I-BET151 DMYRUH2 Discovery agent N.A. Investigative [4]
PMID24000170C36 DMHUWZS Discovery agent N.A. Investigative [5]
PMID24000170C38 DMOLRIY Discovery agent N.A. Investigative [5]
XD14 DMUMACD Discovery agent N.A. Investigative [6]
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Molecule Interaction Atlas

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 BET inhibitors in cancer therapeutics: a patent review.Expert Opin Ther Pat. 2016;26(4):505-22.
3 Discovery and characterization of small molecule inhibitors of the BET family bromodomains. J Med Chem. 2011 Jun 9;54(11):3827-38.
4 Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 2011 Oct 2;478(7370):529-33.
5 Naphthyridines as novel BET family bromodomain inhibitors. ChemMedChem. 2014 Mar;9(3):580-9.
6 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading. Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9.