Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTIGYVZ)

DTT Name	HUMAN eukaryotic initiation factor-4A (eIF4A) DTT Info
Gene Name	EIF4A1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
eFT226	DMHRCQI	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]
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1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hippuristanol	DM0PV2Y	T-cell leukaemia	2A90	Investigative	[2]
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1 Investigative Agents Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Silvestrol	DM5JKNF	Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[3]
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Molecule Interaction Atlas

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References

1	Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase. J Med Chem. 2020 Jun 11;63(11):5879-5955.
2	Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia. Biochem Pharmacol. 2011 Mar 15;81(6):713-22.
3	Broad-spectrum antiviral activity of the eIF4A inhibitor silvestrol against corona- and picornaviruses. Antiviral Res. 2018 Feb;150:123-129.