Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTISP28)

• DTT Name: Retinoic acid receptor beta (RARB) DTT Info
• Gene Name: RARB

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[1]

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[2]

3 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27336223-Compound-10	DMYUP6G	N. A.	N. A.	Patented	[3]
PMID27336223-Compound-7	DM9QM6I	N. A.	N. A.	Patented	[3]
PMID27336223-Compound-8	DM460D1	N. A.	N. A.	Patented	[3]

6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AC261066	DMSKE1I	Discovery agent	N.A.	Investigative	[4]
AC55649	DM4JNY9	Discovery agent	N.A.	Investigative	[4]
AGN193109	DMC0YOE	Discovery agent	N.A.	Investigative	[5]
BMS641	DMRT7G3	Discovery agent	N.A.	Investigative	[6]
CD666	DMC8X9Y	Discovery agent	N.A.	Investigative	[7]
TTNPB	DMSABD0	Discovery agent	N.A.	Investigative	[8]

References

• [1] Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4.
• [2] Tamibarotene: a candidate retinoid drug for Alzheimer's disease. Biol Pharm Bull. 2012;35(8):1206-12.
• [3] Therapeutic use of selective synthetic ligands for retinoic acid receptors: a patent review.Expert Opin Ther Pat. 2016 Aug;26(8):957-71.
• [4] Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. J Med Chem. 2005 Dec 1;48(24):7517-9.
• [5] Therapeutic applications for ligands of retinoid receptors. Curr Pharm Des. 2000 Jan;6(1):25-58.
• [6] Rational design of RAR-selective ligands revealed by RARbeta crystal stucture. EMBO Rep. 2004 Sep;5(9):877-82.
• [7] Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83.
• [8] 9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists. Bioorg Med Chem Lett. 2004 Dec 20;14(24):6117-22.