Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTIV39N)

• DTT Name: Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) DTT Info
• UniProt ID: BCR_HUMAN-ABL1_HUMAN
• Gene Name: BCR-ABL1

Molecule-Related Drug & Molecule List

15 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alkynyl-heteroaromatic ring compound 1	DMEZDQ4	N. A.	N. A.	Patented	[1]
Indazole derivative 5	DMM1I8R	N. A.	N. A.	Patented	[1]
PMID25656651-Compound-19a	DMSNUVZ	N. A.	N. A.	Patented	[1]
PMID25656651-Compound-19b	DMI1Z7D	N. A.	N. A.	Patented	[1]
PMID25656651-Compound-31a	DMSVQMO	N. A.	N. A.	Patented	[1]
PMID25656651-Compound-31b	DM6TGUR	N. A.	N. A.	Patented	[1]
PMID25656651-Compound-31c	DMDJGPC	N. A.	N. A.	Patented	[1]
PMID25656651-Compound-36a	DMNXVY9	N. A.	N. A.	Patented	[1]
PMID25656651-Compound-36b	DMHYDM7	N. A.	N. A.	Patented	[1]
PMID25656651-Compound-36c	DMOGKSW	N. A.	N. A.	Patented	[1]
PMID25656651-Compound-36d	DMKMY4I	N. A.	N. A.	Patented	[1]
PMID25656651-Compound-37a	DM0P4F3	N. A.	N. A.	Patented	[1]
PMID25656651-Compound-37b	DMX98YV	N. A.	N. A.	Patented	[1]
PMID25656651-Compound-37c	DM684IK	N. A.	N. A.	Patented	[1]
Pyrrolo[2,3-b]pyridine derivative 4	DMJBTZG	N. A.	N. A.	Patented	[1]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AP-24163	DMVT6Y3	Discovery agent	N.A.	Investigative	[2]
ON-044580	DMWOHDV	Solid tumour/cancer	2A00-2F9Z	Investigative	[3]

References

• [1] Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412.
• [2] Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP2453... J Med Chem. 2010 Jun 24;53(12):4701-19.
• [3] A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition. Genes Cancer. 2010 Apr;1(4):331-45.