Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTJ8DV7)

• DTT Name: O-6-methylguanine-DNA-alkyltransferase (MGMT) DTT Info
• Gene Name: MGMT

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
O6-Benzylguanine alkylade	DM3L2GT	Sarcoma	2A60-2C35	Phase 3	[1]

6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
6-Allyloxy-9H-purin-2-ylamine	DMI2XUQ	Discovery agent	N.A.	Investigative	[2]
6-Benzyloxy-5-nitro-pyrimidine-2,4-diamine	DMK8XIO	Discovery agent	N.A.	Investigative	[3]
6-Benzyloxy-5-nitroso-pyrimidine-2,4-diamine	DMUFSE2	Discovery agent	N.A.	Investigative	[3]
6-Benzyloxy-9H-purin-2-ylamine	DMFI7A8	Discovery agent	N.A.	Investigative	[3]
Benzylcysteine	DMTCYHM	Discovery agent	N.A.	Investigative	[4]
S-Methylcysteine	DMAMRKS	Discovery agent	N.A.	Investigative	[4]

References

• [1] Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. J Clin Oncol. 2009 Mar 10;27(8):1262-7.
• [2] Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)gua... J Med Chem. 2000 Nov 2;43(22):4071-83.
• [3] Inhibition of human O6-alkylguanine-DNA alkyltransferase and potentiation of the cytotoxicity of chloroethylnitrosourea by 4(6)-(benzyloxy)-2,6(4)-... J Med Chem. 1998 Feb 12;41(4):503-8.
• [4] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.