Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTJ8E43)

• DTT Name: Apelin receptor (APLNR) DTT Info
• Gene Name: APLNR

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AMG 986	DMZQ2DK	Heart failure	BD10-BD13	Phase 1	[1]

4 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
apelin-13	DM2CKUZ	Discovery agent	N.A.	Investigative	[2]
E339-3D6	DMGPRT7	Discovery agent	N.A.	Investigative	[3]
ML221	DM3OEP4	Discovery agent	N.A.	Investigative	[4]
ML233	DM8CIE4	Discovery agent	N.A.	Investigative	[5]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Structural and functional study of the apelin-13 peptide, an endogenous ligand of the HIV-1 coreceptor, APJ. Biochemistry. 2003 Sep 2;42(34):10163-8.
• [3] Identification and pharmacological properties of E339-3D6, the first nonpeptidic apelin receptor agonist. FASEB J. 2010 May;24(5):1506-17.
• [4] Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6656-60.
• [5] Functional Agonists of the Apelin (APJ) Receptor. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010.