Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTJGLZF)

• DTT Name: Dipeptidyl peptidase 8 (DPP-8) DTT Info
• Gene Name: DPP8

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Talabostat	DM1IZ5D	Constitutional neutropenia	4B00.0	Phase 3	[1]
BXCL701	DMBPUIK	Prostate cancer	2C82.0	Phase 1/2	[2]

2 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thiomorpholine derivative 1	DMZP6KR	N. A.	N. A.	Patented	[3]
Thiomorpholine derivative 2	DMWOK1D	N. A.	N. A.	Patented	[3]

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1G244	DMEB8CG	Discovery agent	N.A.	Investigative	[4]
PMID15664838C18	DM93RKC	Discovery agent	N.A.	Investigative	[5]
PMID20684603C24dd	DMWZK9U	Discovery agent	N.A.	Investigative	[6]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal adenocarcinoma. J Immunother Cancer. 2021 Nov;9(11):e002837.
• [3] DPP-4 inhibitors: a patent review (2012 - 2014).Expert Opin Ther Pat. 2015 Feb;25(2):209-36.
• [4] Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem Pharmacol. 2009 Jul 15;78(2):203-10.
• [5] Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8. Bioorg Med Chem Lett. 2005 Feb 1;15(3):687-91.
• [6] Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J Med Chem. 2010 Aug 12;53(15):5620-8.