Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTJNTSI)

• DTT Name: Rotamase Pin1 (PIN1) DTT Info
• Gene Name: PIN1

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[1]

10 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(R)-2-(2-naphthamido)-3-m-tolylpropanoic acid	DMVEMNA	Discovery agent	N.A.	Investigative	[2]
(R)-2-(2-naphthamido)-3-p-tolylpropanoic acid	DMXGCYZ	Discovery agent	N.A.	Investigative	[2]
(R)-2-(2-naphthamido)-5-phenylpent-4-ynoic acid	DM9WL6O	Discovery agent	N.A.	Investigative	[2]
(R)-3-(2-naphthamido)-4-m-tolylbutanoic acid	DM5TH2W	Discovery agent	N.A.	Investigative	[2]
(R,)-2-(2-naphthamido)-5-phenylpent-4-enoic acid	DMCW5A9	Discovery agent	N.A.	Investigative	[2]
3,6,9,12,15,18-HEXAOXAICOSANE	DMY26JI	Discovery agent	N.A.	Investigative	[3]
Ac-Bth-Thr(PO3H2)-Pip-Nal-Gln-NH2	DMSE29N	Discovery agent	N.A.	Investigative	[4]
Ac-Phe-D-Thr(PO3H2)-Pip-Nal-Gln-NH2	DM6ONY7	Discovery agent	N.A.	Investigative	[4]
Ac-Phe-Thr(PO3H2)-Pip-Nal-Gln-NH2	DMSWTPX	Discovery agent	N.A.	Investigative	[4]
Beta-(2-Naphthyl)-Alanine	DMP21ZO	Discovery agent	N.A.	Investigative	[3]

References

• [1] Overexpression of PIN1 Enhances Cancer Growth and Aggressiveness with Cyclin D1 Induction in EBV-Associated Nasopharyngeal Carcinoma.PLoS One. 2016 Jun 3;11(6):e0156833.
• [2] Structure-based design of novel human Pin1 inhibitors (II). Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4.
• [3] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [4] Nanomolar inhibitors of the peptidyl prolyl cis/trans isomerase Pin1 from combinatorial peptide libraries. J Med Chem. 2006 Apr 6;49(7):2147-50.