Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTJO6E9)

DTT Name	Gap junction protein (GJP) DTT Info
Gene Name	GJP

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Clinical Trial Drug(s)

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2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Danegaptide	DM2U45Q	Atrial fibrillation	BC81.3	Phase 2	[1]
ROTIGAPTIDE	DMXB9RS	Cardiac arrhythmias	BC9Z	Phase 2	[2]
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Molecule Interaction Atlas

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References

1	The gap junction modifier, GAP-134 [(2S,4R)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], improves conduction and reduces atrial fibrillation/flutter in the canine sterile pericarditis model. J Pharmacol Exp Ther. 2009 Jun;329(3):1127-33.
2	The antiarrhythmic peptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin 43. Br J Pharmacol. 2006 Mar;147(5):486-95.