Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTJQT60)

• DTT Name: TGF-beta-activated kinase 1 (MAP3K7) DTT Info
• Gene Name: MAP3K7

Molecule-Related Drug & Molecule List

3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZ-TAK1	DMD4LGN	Mantle cell lymphoma	2A85.5	Investigative	[1]
NG-25	DMC48D9	Discovery agent	N.A.	Investigative	[2]
PMID23099093C17d	DMWS7O9	Discovery agent	N.A.	Investigative	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2082).
• [2] Discovery of type II inhibitors of TGFbeta-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96.
• [3] Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73.