General Information of DTT (ID: TTJW7B3)

DTT Name P2X purinoceptor 1 (P2RX1) DTT Info
Gene Name P2RX1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Investigative Drug(s)
7 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
BzATP DM37GYA Discovery agent N.A. Investigative [1]
Ip5I DMB2YXN Discovery agent N.A. Investigative [1]
L-betagamma-meATP DMTNQCE Discovery agent N.A. Investigative [1]
MRS 2219 DM7IK68 Discovery agent N.A. Investigative [2]
NF023 DMJ4GO9 Discovery agent N.A. Investigative [1]
NF449 DM816Z2 Discovery agent N.A. Investigative [3]
TNP-ATP DMVZY0X Discovery agent N.A. Investigative [4]
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⏷ Show the Full List of 7 Investigative Drug(s)
Molecule Interaction Atlas

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 478).
2 A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonize activation of P2X1 receptors. J Med Chem. 1998 Jun 18;41(13):2201-6.
3 Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist. Eur J Med Chem. 2004 Apr;39(4):345-57.
4 Trinitrophenyl-substituted nucleotides are potent antagonists selective for P2X1, P2X3, and heteromeric P2X2/3 receptors. Mol Pharmacol. 1998 Jun;53(6):969-73.