Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTK3C21)

• DTT Name: Acetoacetyl-CoA thiolase (ACAT1) DTT Info
• Gene Name: ACAT1

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ATR-01	DMU67HD	Adrenocortical carcinoma	2D11.Z	Phase 1	[1]

1 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID25470667-Compound-K-604	DMYZ2UA	N. A.	N. A.	Patented	[2]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benoxaprofen	DM5ZOX8	Inflammation	1A00-CA43.1	Withdrawn from market	[3]

13 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(Z)-2,6-diisopropyl-N-phenyloctadec-9-enamide	DMFLDPU	Discovery agent	N.A.	Investigative	[4]
Nonanoic acid biphenyl-2-ylamide	DM951PF	Discovery agent	N.A.	Investigative	[4]
Octanoic acid biphenyl-2-ylamide	DM4RGCX	Discovery agent	N.A.	Investigative	[4]
PMID16242323C15a	DMM4A7P	Discovery agent	N.A.	Investigative	[5]
PMID16242323C15b	DM7U3RM	Discovery agent	N.A.	Investigative	[5]
PMID16242323C16	DM2Q79X	Discovery agent	N.A.	Investigative	[5]
PMID16242323C18a	DMI5WPQ	Discovery agent	N.A.	Investigative	[5]
PMID16242323C18b	DMIS7NT	Discovery agent	N.A.	Investigative	[5]
PMID16242323C22c	DMFDRMH	Discovery agent	N.A.	Investigative	[5]
PMID16242323C22d	DMJICNL	Discovery agent	N.A.	Investigative	[5]
PMID16242323C26a	DMD0Q7K	Discovery agent	N.A.	Investigative	[5]
PMID16242323C26b	DMF0VLX	Discovery agent	N.A.	Investigative	[5]
PMID16242323C26c	DMT3EU2	Discovery agent	N.A.	Investigative	[5]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58.
• [3] Inhibition of lyso-PAF: acetyl-CoA acetyltransferase by salicylates and other compounds. Prostaglandins. 1988 Jun;35(6):939-44.
• [4] Biphenyl versus phenylpyridazine derivatives: the role of the heterocycle in a series of acyl-CoA:cholesterol acyl transferase inhibitors. J Med Chem. 2008 Mar 13;51(5):1474-7.
• [5] Synthesis and biological activity of novel 4-phenyl-1,8-naphthyridin-2(1H)-on-3-yl ureas: potent acyl-CoA:cholesterol acyltransferase inhibitor wit... Bioorg Med Chem Lett. 2006 Jan 1;16(1):44-8.